Apogossypolone targets mitochondria and light enhances its anticancer activity by stimulating generation of singlet oxygen and reactive oxygen species OACSCDCSTPCD
Apogossypolone targets mitochondria and light enhances its anticancer activity by stimulating generation of singlet oxygen and reactive oxygen species
Apogossypolone (ApoG2), a novel derivative of gossypol, has been shown to be a potent inhibitor of antiapoptotic Bcl-2 family proteins and to have antitumor activity in multiple types of cancer cells. Recent reports suggest that gossypol stimulates the generation of cellular reactive oxygen species (ROS) in leukemia and colorectal carcinoma cells; however, gossypol-mediated cell death in leukemia cells was reported to be ROS-independent. This study was condu…查看全部>>
Zhe-Yu Hu;Jing Wang;Gang Cheng;Xiao-Feng Zhu;Peng Huang;Dajun Yang;Yi-Xin Zeng
State Key Laboratory of Oncology in South China,Guangzhou,Guangdong 510060,P.R.ChinaDepartment of Experimental Research,Sun Yat-sen University Cancer Center,Guangzhou,Guangdong 510060,P.R.ChinaThe First Hospital of Changsha City,Changsha,Hunan 410005,P.R.ChinaState Key Laboratory of Oncology in South China,Guangzhou,Guangdong 510060,P.R.ChinaDepartment of Experimental Research,Sun Yat-sen University Cancer Center,Guangzhou,Guangdong 510060,P.R.ChinaDepartrnent of Molecular Pathology,The University of Texas MD Anderson Cancer Center,Houston,Texas 77030,USAState Key Laboratory of Oncology in South China,Guangzhou,Guangdong 510060,P.R.China
Apogossypolone mitochondria singlet oxygen reactive oxygen species photodynamic therapy
Apogossypolone mitochondria singlet oxygen reactive oxygen species photodynamic therapy
《癌症》 2011 (1)
41-53,13
评论