四川大学学报（医学版）2011，Vol.42Issue(1)：86-89,4.
铂耐药和铂敏感上皮性卵巢癌中ERCC1、survivin蛋白的表达及临床应用价值
The Protein Expression of ERCC1 and Survivin in Epithelial Ovarian Carcinoma and Their Clinical Significance
谢聪 1尹如铁 1李玉玲 1康德英 2徐炼 3杨开选3
作者信息
- 1. 四川大学华西第二医院妇产科,成都,610041
- 2. 四川大学华西医院临床流行病学教研室,成都,610041
- 3. 四川大学华西第二医院病理科,成都,610041
- 折叠
摘要
Abstract
Objective To investigate the protein expression of ERCC1 (excision repair cross complementation group 1) and survivin gene in platinum-resistant and platinum-sensitive epithelial ovarian carcinoma (EOC), and to explore the relationship among ERCC1 expression, survivin expression, the major clinicopathological charactetistics as well as platinum sensitivity. Methods Expression of ERCC1 and survivin were detected in 64 EOC tissues by immunohistochemical method. Results No significant differences were found in patients' age, FIGO stage,pathological type, histological grade, pelvic lymph node and/or vessel infiltration, in all of three pairs of comparison. They were platinum-sensitive group vs. platinum-resistant group, ERCCl-positve group vs. ERCC1-negative group and surviving-positive group vs. survivn-negative group (all P＞0.05). The positive rate of ERCC1 expression (67.85％, 19/28) in platinum-resistant patients' tissues was significantly higher than that in platinumsensitive patients' tissues (25.00％, 9/36) (P= 0.001). While the positive rate of survivin in platinum-resistant patients' tissues (78.57％, 22/28) was slightly higher than that of in platinum-sensitive patients' tissues (75.00％, 29/36), however without significant (P=0.74). No evidence was found that the expression of ERCC1 correlate with the expression of survivin (rs = 0.12, P= 0.36) too. The proportion of platinum-resistant in patients with coexpression of ERCC1 and surviving (65.22 ％, 15/23) was insignificantly lower than that of in patients with single expression of ERCC1 (80.00％, 4/5) (P= 0.91). Conclusion Expression of ERCC1 in EOC patients'tumor tissue could be a predictive indicator fortheir platinum susceptibility and it might be helpful for prevention and reverse of platinum resistance in clinical practice. The expression of survivin seems of no definite value in prediction of platinum susceptibility.关键词
ERCC1/生存素/上皮性卵巢癌/铂耐药/铂敏感Key words
ERCC1 / Survivin / Epithelial ovarian carcinoma / Platinum-resistant / Platinumsensitive引用本文复制引用
谢聪,尹如铁,李玉玲,康德英,徐炼,杨开选..铂耐药和铂敏感上皮性卵巢癌中ERCC1、survivin蛋白的表达及临床应用价值[J].四川大学学报（医学版）,2011,42(1):86-89,4.
