中国肺癌杂志2011，Vol.14Issue(1)：49-53,5.DOI:10.3779/j.issn.1009-3419.2011.01.10
uPA、ET-1蛋白在非小细胞肺癌中的表达及其临床相关性
Expression and Clinical Relevance of uPA and ET-1 in Non-small Cell Lung Cancer
摘要
Abstract
Background and objective uPA and ET-1 proteins have been reported to be up-regulated in some of human cancers. The aim of this study is to investigate the alteration and clinical relevance of uPA and ET-1 protein levels in non-small cell lung cancer (NSCLC). Methods Expressions of uPA and ET-1 protein were detected in 155 cases of NSCLC with tissue microarrays and immunohistochemistry (TMA-IHC) technique. The correlations between the alteration of the two proteins and clinicopathological parameters were analyzed. Results Negative/weak, moderate and high expression of uPA were observed in 12.3％, 64.4％ and 23.3％ of squamous cell carcinomas, in 12.2％, 53.7％ and 34.1％ of adenocarcinomas,and in 12.3％, 58.7％ and 29.0％ of all cases. ET-1 presented negative/weak, moderate and high expression in 2.7％, 42.5％ and 54.8％ of squamous cell carcinomas, in 11.0％, 30.5％ and 58.5％ ofadenocarcinomas, and in 7.1％, 36.1％ and 56.8％ of all cases.Simultaneously high expression of uPA and ET-1 were found in adenocarcinomas without lymph node metastasis (P=0.017).Adenocarcinoma patients with high expression of uPA or with high expression of both ET-1 and uPA had the longer survival time (P=0.007 and 0.016). Conclusion Detection of uPA and ET-1 protein levels might contribute to the prognosis evaluation of NSCLC.关键词
肺肿瘤/uPA/ET-1/免疫组织化学/预后分类
医药卫生引用本文复制引用
蒋焱熠,刘一臻,史志周,王博石,商利,徐昕,张盛周,王明荣..uPA、ET-1蛋白在非小细胞肺癌中的表达及其临床相关性[J].中国肺癌杂志,2011,14(1):49-53,5.基金项目
本研究受卫生行业公益专项基金(No.200902002-4)和国家自然科学基金重点项目(No.30630067)资助 （No.200902002-4）
