临床肝胆病杂志2011，Vol.27Issue(1)：103-106,4.
结缔组织生长因子与肝脏纤维化
The relationship between connective tissue growth factor and hepatic fibrosis
谢永鹏 1臧秀贤 1吴扬 1李迎今 1张楠1
作者信息
- 1. 吉林大学第一医院急诊科,长春,130021
- 折叠
摘要
Abstract
The connective tissue growth factor(CTGF) can enhance the proliferation of fibroblasts and promote the extra cellular matrix synthesis.It is an important cytokine that can promote organ fibrosis.There is a strong correlation between the CTGF and hepatic fibrosis.The CTGF expression of human hepatic fibrosis, cirrhosis and experimental hepatic fibrosis model is significantly rising.The inhibition of CTGF expression can reduce the extra cellular matrix synthesis, resulting in the inhibition of hepatic fibrosis.The further study of CTGF is important for the pathogenesis, therapeutic mechanism and the clinical treatment of hepatic fibrosis and cirrhosis.In the review, the function of CTGF and its state on the pathogenic process, diagnosis and treatment of hepatic fibrosis were summarized and discussed.关键词
胞间信号肽类和蛋白质类/即早蛋白质类/肝硬化Key words
intercellular signaling peptides and proteins/ immediate-early proteins/ liver cirrhosis分类
医药卫生引用本文复制引用
谢永鹏,臧秀贤,吴扬,李迎今,张楠..结缔组织生长因子与肝脏纤维化[J].临床肝胆病杂志,2011,27(1):103-106,4.
