中国实用内科杂志2011，Vol.31Issue(1)：39-41,3.
强化胰岛素治疗后2型糖尿病夜间低血糖及其与睡前血糖关系的研究
Association between nocturnal hypoglycemia and glucose at bedtime in type 2 diabetic patients receiving intensive insulin therapies
许丽娟 1李焱 2梁骏 3严励 2程桦 2傅祖植2
作者信息
- 1. 中山大学附属第一医院内分泌科,广州,510080
- 2. 中山大学附属第二医院内分泌科,广州,510120
- 3. 广东省人民医院,广州,510080
- 折叠
摘要
Abstract
Objective To investigate the occurrence of nocturnal hypoglycemia in type 2 diabetic patients receiving intensive insulin therapies and to study the association between asymptomatic nocturnal hypoglycemia with glucose at bedtime or after supper. Methods Forty-five type 2 diabetic inpatients were randomly divided into three groups:fifteen patients received thrice preprandial hypodermic injection of premix insulin analog, another fifteen patients received thrice preprandial insulin aspart and once insulin glargin at bedtime, and the others received thrice preprandial regular insulin and once intermediate-acting insulin at bedtime. After blood glucose reaching the treatment target, continuous glucose monitoring system was used to inspect the control of glucose and occurrence of hypoglycemia for 72 h. Results Continuous glucose monitoring system showed that the incidence of hypoglycemia (glucose no more than 3.9 mmol/L) was up to 79.5％, and 86％ of them had nocturnal hypoglycemia; all patients were not aware of nocturnal hypoglycemia. The contingency coefficient of bedtime glucose with incidence of nocturnal hypoglycemia was 0.26( P ＜ 0.05 ). While postprandial glucose had no relation with nocturnal hypoglycemia( r = 0.15 ,P ＞0.05 ). Conclusion Incidence of nocturnal hypoglycemia unawareness is extremely high in.type 2 diabetic patients receiving intensive insulin therapies. Bedtime glucose might be a more appropriate parameter to infer nocturnal hypoglycemia than postprandial glucose.关键词
强化胰岛素治疗/动态血糖监测/夜间未察觉低血糖分类
医药卫生引用本文复制引用
许丽娟,李焱,梁骏,严励,程桦,傅祖植..强化胰岛素治疗后2型糖尿病夜间低血糖及其与睡前血糖关系的研究[J].中国实用内科杂志,2011,31(1):39-41,3.
