中国实用内科杂志2011，Vol.31Issue(1)：42-44,3.
妊娠糖尿病患者分娩后胰岛素抵抗和胰岛B细胞功能研究
Insulin resistance and B cell function after delivery in gestational diabetes mellitus
摘要
Abstract
Objective To investigate insulin resistance and B cell function after delivery in the gestational diabetes mellitus(GDM). Methods According to oral glucose tolerance test ( OGTT),8 women with a history of GDM and normal glucose tolerance were take as NGT group. Another 8 women with a history of GDM and impaired glucose tolerance were take as IGT group. Insulin resistance was measured using hyperinsulin-euglycemic clamp,and B-cell function was assessed by intravenous glucose tolerance test (IVGTT). Results BMI and triglyceride in NGT group and IGT group were similar. The glucose injection rate of IGT group was lower than that in NGT group(5. 70 ± 1.14 vs 7.79 ± 1.75, P ＜ 0. 05 ). The first phase insulin secretion of NGT group was higher than that of IGT group(5. 32 ± 0. 37 vs 4. 35 ± 0. 46,P ＜ 0. 05 ); there was no difference between the IGT group and the NGT group at the second phase (4. 35 ± 0. 31 vs 4. 38 ± 0. 56, P ＞ 0. 05 ). Conclusion There is more severe insulin resistance and more severe B cell function impairment in women with a history of GDM and impaired glucose tolerance than in those with normal glucose tolerance.关键词
妊娠糖尿病/胰岛素抵抗/B细胞功能/正葡萄糖高胰岛素钳夹技术/静脉葡萄糖耐量试验分类
医药卫生引用本文复制引用
陈宇,王立伟,李玲,厉平,石英,刘玉辉,刘聪..妊娠糖尿病患者分娩后胰岛素抵抗和胰岛B细胞功能研究[J].中国实用内科杂志,2011,31(1):42-44,3.基金项目
辽宁省科学技术计划(2008225009-21) （2008225009-21）
辽宁省教育厅资助课题(05L482) （05L482）
