中国实用内科杂志2011，Vol.31Issue(1)：76-78,3.
利奈唑胺治疗中性粒细胞减少血液病革兰阳性球菌感染76例临床分析
Linezolid in treatment of neutrocytopenia hematopathy patients with gram positive coccobacteria infection
摘要
Abstract
Objective To analyze the curative effect and safety of Linezolid in treatment of neutrocytopenia hematopathy patients with G+ coccobacteria infection. Methods Totally 76 neutrocytopenia hematopathy patients suspected of G+ coccobacteria infection,were treated with linezolid(600 mg,once every 12 hours). We evaluated the curative effect based on clinical situation and aetiology;meanwhile,we observed the drug adverse reaction. Resuits The total effective rate of linezolid was 91.26％. For 13 patients only having linezolid,the effective rate was 92. 31％ ;for 27 patients treated with linezolid from the beginning of combined infection, effective rate was 92. 59％ ;for 36 patients treated with other anti-G + coccobacteria drugs from the beginning of combined infection then changed to linezolid,effective rate was 88. 89％. The body temperature control meso-time were 3. 31 days,3. 76 days and 6. 58 days in the 3 groups. In complete remission in malignancy hematopathy,long term use of antibiotic and affiliating G- coccobacteria were the three main factors ngainst the curative effect of linezolid. The adverse effect incidence rate was 26. 31％ ;8 patients recovered from slight abnormal liver function or renal function one week after stopping linezolid. Conclusion Linezolid is effective in treating granulocytopenia hematopathy patients' G+ coccobacteria infection. When using only linezolid in the case of mild G+ coccobacterin infection, the curative effect is obvious. It's better for severe polyinfection to use linezolid at the beginning. Malignancy hematopathy complete remission, avoidance of long term antibiotic use and timely and effective pathogen inspection are three factors to emhance the curative effect of anti G + coccobacteria of linezolid.关键词
利奈唑胺/革兰阳性球菌/粒细胞减少/血液病分类
医药卫生引用本文复制引用
王秀丽,胡晓慧,薛胜利,徐明珠,吴德沛,孙爱宁,仇惠英,苗瞄,唐晓文,付铮铮,何广胜..利奈唑胺治疗中性粒细胞减少血液病革兰阳性球菌感染76例临床分析[J].中国实用内科杂志,2011,31(1):76-78,3.基金项目
江苏省医学领军人才基金(LJ200626) （LJ200626）
卫生部专项基金(200802027) （200802027）
