中国肺癌杂志2011，Vol.14Issue(1)：28-32,5.DOI:10.3779/j.issn.1009-3419.2011.01.06
Tissue Carcinoembryonic Antigen, Calcium, Copper and Iron Levels in Cancerous Lung Patients
Tissue Carcinoembryonic Antigen, Calcium, Copper and Iron Levels in Cancerous Lung Patients
Nasar Yousuf ALWAHAIBI 1Jokha Sultan ALGHARIBI 1Amna Salim ALSHUKAILI 1Ahmed Khalifa ALSHUKAILI2
作者信息
- 1. Department of Pathology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman
- 2. Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman
- 折叠
摘要
Abstract
Background and objective The expression of various trace elements and markers in lung cancer is controversial. The aim of this study is to evaluate the presence of calcium (Ca), copper (Cu), iron (Fe) and carcinoembryonic antigen (CEA) in cancerous untreated lung tissues and to determine a possible association between these markers and lung cancer.Methods Fourty-eight cancerous lung tissue blocks, from Sultan Qaboos University Hospital, Sultanate of Oman, were studied. Fe, Ca, Cu, and CEA were demonstrated in the tissue blocks using Perl's Prussian blue, Von Kossa's, modified rhodanine and immunohistochemical staining methods, respectively.Results Twenty-three of 48 specimens showed positive Fe staining, 2 showed positive Ca staining and Cu was absent in all specimens. 93.7% expressed CEA in varying degree of positivity. 81.25% of these sections showed high expression of CEA. Conclusion Tissue concentrations of trace elements were not elevated in lung cancer and therefore cannot be considered as a potential marker. Despite the low sensitivity and specificity of CEA as previously reported, tissue CEA should be considered as a potential marker in the evaluation of lung cancer.关键词
Calcium/Copper/Iron/Human CEA protein/Immunohistochemistry/Lung neoplasmsKey words
Calcium/Copper/Iron/Human CEA protein/Immunohistochemistry/Lung neoplasms引用本文复制引用
Nasar Yousuf ALWAHAIBI,Jokha Sultan ALGHARIBI,Amna Salim ALSHUKAILI,Ahmed Khalifa ALSHUKAILI..Tissue Carcinoembryonic Antigen, Calcium, Copper and Iron Levels in Cancerous Lung Patients[J].中国肺癌杂志,2011,14(1):28-32,5.
