肿瘤防治研究2011，Vol.38Issue(1)：41-44,4.DOI:10.3971/j.issn.1000-8578.2011.01.012
鼻咽癌组织中HIF-2α和Caspase-3的表达及意义
Expression and Significance of HIF-2α and Caspase-3 in Nasopharyngeal Carcinoma
摘要
Abstract
Objective To explore the expression and clinical significance of HIF-2α and Caspase-3 in nasopharyngeal carcinoma(NPC). Methods The expression of HIF-2α and Caspase-3 protein were examined by immunochemistry in 46 samples of NPC and 20 samples of chronic nasopharynxitis. Results The expression of HIF-2α protein in NPC was higher than that in chronic nasopharynxitis while Caspase-3 protein was opposite (P＜0. 05). No statistical significance were observed between the expression of H IF-2α protein and patients gender, age, clinical staging and lymph node metastasis (P＞ 0. 05). There were significant statistical correlations between overexpression of HIF-2α protein and T stage. The expression of Caspase-3 was not significantly correlated with patients gender, age, T stage, clinical staging, and lymph node metastasis (P＞0. 05). There was no correlation between the expression of HIF-2α protein and Caspase-3 protein expression in NPC(r= -0. 195,P＞0. 05). Conclusion The anomalous expression of HIF-2α and Caspase-3 may be associated with the carcinogenesis and development of NPC. There was significant correlation between the higher expression of HIF-2α protein and the malignant progression of NPC.关键词
鼻咽肿瘤/HIF-2α/Caspase-3/免疫组织化学分类
医药卫生引用本文复制引用
丁晖,李先明,高艳,胡丽霞,杨东,周亚燕,徐钢..鼻咽癌组织中HIF-2α和Caspase-3的表达及意义[J].肿瘤防治研究,2011,38(1):41-44,4.基金项目
广东省深圳市科技计划项目资金资助项目(200702102) （200702102）
