中国全科医学2011，Vol.14Issue(6)：611-613,3.
女性生殖生育因素与系统性红斑狼疮关系的研究
Study on the Relation between Female Reproductive Factors and Development of Systemic Lupus Erythematosus in Women
摘要
Abstract
Objective To examine the associations between female reproductive and menopausal factors and the development of systemic lupus erythematosus ( SLE ), in order to provide the etiology and clues for primary prevention of SLE. Methods A case - control study was conducted on 121 case and 122 controls from the general hospital of Tianjin Medical University by using univariate and multivariate unconditional Logistic regression model to analyze the relative risk factors like physical data, menopausal factors. Results Univariate unconditional Logistic regression model showed that induced abortion [ OR =7. 53, 95％ CI ( 3. 09, 18. 36 ) ], sterilization operation [ OR = 30. 04, 95％ CI ( 3. 88, 232. 92 ) ], menstrual flow [ OR = 2. 39, 95％ CI ( 1. 12, 5. 16 ) ] , menstrual irregularity [ OR = 4. 05 , 95％ CI ( 1. 67 , 9. 82 ) ], mother's age when born [ OR = 1. 08, 95％ CI ( 1. 02, 1. 15 ) ], age at menarche [ OR = 0. 67, 95％ CI ( 0. 57, 0. 80 ) ], age at menopause [ OR = 0. 55, 95％ CI ( 0. 42, 0. 71 ) ] were associated with SLE ( P ＜0. 05 ). Multivariate unconditional Logistic regression model showed that the risk factors of SLE including induced abortion [ OR =7. 53 , 95％ CI ( 3. 09, 18. 36 ) ], age at menarche [ OR =0. 67, 95％ CI ( 0. 57, 0. 80 ) ], age at menopause [ OR = 0. 51, 95％ CI ( 0. 39, 0. 67 ) ], menstrual irregularity [ OR = 4. 05, 95％CI (1.67, 9.82)]. Conclusion Early age at menarche and menopause, induced abortion and menstrual irregularity were associated with SLE. These associations may be involved in the mechanisms underlying the pathogenesis of SLE.关键词
红斑狼疮,系统性/危险因素/生育史/回归分析/病例对照研究分类
医药卫生引用本文复制引用
柯慧,李长平,崔壮,孙旻 ,魏凤江,魏蔚,马骏..女性生殖生育因素与系统性红斑狼疮关系的研究[J].中国全科医学,2011,14(6):611-613,3.基金项目
全国统计科学研究计划项目(2009LY011) （2009LY011）
天津市应用基础与前沿技术研究计划重点项目(08JCZDJC21400) （08JCZDJC21400）
国家自然科学基金青年科学基金项目(21003077) （21003077）
