西南国防医药2011，Vol.21Issue(1)：8-11,4.DOI:10.3969/j.issn.1004-0188.2011.01.003
血管内皮生长因子C和D在非小细胞肺癌细胞和转移淋巴结中的表达
Expression of vascular endothelial growth factor-C and -D in non-small——cell lung cancer and metastatic lymph nodes
摘要
Abstract
Objective To explore the expression of vascular endothelial growth factor - C and - D( VEGF - C and - D )in non -small - cell lung cancer( NSCLC )and their relationships with lymph node metastasis. Methods The expression of VEGF - C and - D in cancer tissues, adjacent cancer tissues and 146 lymph nodes from 40 cases of NSCLC as well as in normal lung tissues from 11 cases of pulmonary benign lesion was detected by immunohistochemical method. Results The positive rate of VEGF - C and - D expression in NSCLC was significantly higher than that in normal lung tissues and adjacent cancer tissues( P ＜ 0. 01 ). Patients with lymph node metastasis had significantly higher positive rate of VEGF - C and - D expression than those without lymph node metastasis( P ＜0. 05 ).In addition,VEGF - C and - D expression were significantly higher in NSCLC patients with stageⅢ + Ⅳ than those with stage Ⅰ + Ⅱaccording to TNM staging( P ＜0. 05 ). However. VEGF - C and - D expression showed no significant correlation with age , sex, tumor size,histological type and differentiation degree( P ＞0.05 ). Conclusion The high expression of VEGF - C and - D appears to be closely related to TNM staging and lymph node metastasis in patients with NSCLC , which implicates that they may play important roles in the growth invasion and lymph node metastasis of NSCLC.关键词
非小细胞肺癌/血管内皮生长因子/淋巴结转移/免疫组织化学分类
医药卫生引用本文复制引用
石云,张利斌,王平,熊健,张利,罗国军,赵青,陈瑜,李卓东..血管内皮生长因子C和D在非小细胞肺癌细胞和转移淋巴结中的表达[J].西南国防医药,2011,21(1):8-11,4.基金项目
云南省科技厅科研基金资助(2008ZC086M) （2008ZC086M）
