疑难病杂志2011，Vol.10Issue(1)：13-15,3.DOI:10.3969/j.issn.1671-6450.2011.01.005
新生儿缺氧缺血性脑病血清IL-10、MCP-1变化及临床意义
The significance of serum IL-10 and MCP-1 in newborn infants with hypoxic ischemic encephalopathy
刘克宇 1张重梅 1宋庆云 1岳巧莲 1高娟梅 1武俊梅 1赵文静1
作者信息
- 1. 056001,河北省邯郸市人民医院检验科
- 折叠
摘要
Abstract
Objective To explore the changes and clinical significance of serum IL-10 and MCP-1 in newborn infants with hypoxic ischemic encephalopathy ( HIE ). Methods Sixty-four newborn infants were diagnosed for HIE, which were divided into mild HIE group ( n =29 ), moderate HIE group ( n = 17 ) and severe HIE group ( n = 18 ). 41 normal newborn infants were enrolled as control group. The serum concentrations of IL-10 were detected using RIA, and the level of MCP-1 was detected with ELISA. The results were statistically analyzed. Results ( 1 ) The levels of IL-10 and MCP-1 of acute phase HIE group were higher than that of control group ( P ＜0.01 ), also higher than that of recovery phase HIE group ( P ＜0.01 ). The differences between recovery phase HIE group and control group were not significant( P ＞ 0.05 ). ( 2 ) In severe HIE groups, the serum IL-10 and MCP-1 levels were higher than those of moderate HIE group( all P ＜ 0.05 )and mild HIE group( all P ＜ 0.05 ). ( 3 )The serum concentrations of IL-10 in acute and recovery phase HIE groups were positively correlated with those of MCP-1( r =0.851, r =0.832,all P ＜0.05 ), the serum concentrations of IL-10 of severe,moderate and mild HIE groups were positively correlated with those of MCP-I( r = 0. 846, r = 0. 835, r = 0. 827,all P ＜ 0.05 ). Conclusion Serum IL-10 and MCP-1 levels could be used as reference of disease severity and recovery effect of HIE.关键词
新生儿/缺氧缺血性脑病/白细胞介素-10/MCP-1引用本文复制引用
刘克宇,张重梅,宋庆云,岳巧莲,高娟梅,武俊梅,赵文静..新生儿缺氧缺血性脑病血清IL-10、MCP-1变化及临床意义[J].疑难病杂志,2011,10(1):13-15,3.
