疑难病杂志2011，Vol.10Issue(1)：40-42,3.DOI:10.3969/j.issn.1671-6450.2011.01.019
小剂量阿司匹林对动脉粥样硬化兔主动脉MMP-2表达的影响
Effect of low dose aspirin on the expression of MMP-2 in the aorta of atherosclerotic rabbit
姜昕 1郭毅 2左彦方 2李方明 2刘华东 1庞新利1
作者信息
- 1. 518020,暨南大学第二临床医学院/深圳市人民医院心内科
- 2. 518020,暨南大学第二临床医学院/深圳市人民医院神经内科
- 折叠
摘要
Abstract
Objective To evaluate the effect of low dose aspirin on the severity of atherosclerosis and the expression of metalloproteinase-2 ( MMP-2 ) in the aorta of atherosclerotic rabbit. Methods 24 male New Zealand rabbits were randomly divided into control group ( normal rabbit diet), model group ( high cholesterol diet ), aspirin group ( high cholesterol diet and low dose aspirin ), 8 rabbits in each group. After 12 weeks, animals were killed,and the aorta were obtained for pathological examination. RT-PCR and Western blot were used to analyze MMP-2 mRNA and protein expression respectively. Results The maximal plaque thickness, average plaque thickness, degree of aortic luminal stenosis and the ratio between plaque and lumen circumference in 3 groups were significantly different from each other ( P ＜ 0. 01 ). The expressions of MMP-2 protein and mRNA in atherosclerotic groups were significantly higher than that in normal control group; but the expressions of MMP-2 protein and mRNA were reduced respectively ( P ＜ 0. 01 ) in the low dose aspirin group compared with the model group. Conclusion The expression of MMP-2 is low in normal vascular and gradually increased with the severity degree of atherosclerosis. Low dose aspirin can significantly reduce the expression of MMP-2 and the severity of atherosclerosis.关键词
阿司匹林/动脉粥样硬化/基质金属蛋白酶-2/新西兰兔引用本文复制引用
姜昕,郭毅,左彦方,李方明,刘华东,庞新利..小剂量阿司匹林对动脉粥样硬化兔主动脉MMP-2表达的影响[J].疑难病杂志,2011,10(1):40-42,3.
