中国病理生理杂志2011，Vol.27Issue(1)：187-190,195,5.DOI:10.3969/j.issn.1000-4718.2011.01.037
ROS介导的自噬及其在相关疾病中的作用
ROS-mediated autophagy and its role in the pathogenesis
摘要
Abstract
Reactive oxygen species ( ROS ) are generally small, short - lived and highly reactive molecules,and formed by incomplete one - electron reduction of oxygen. ROS act as signaling molecules involving in a variety of intracellular processes, such as proliferation, immunity and apoptosis. The intracellular excessive accumulation of ROS may cause oxidative stress, and eventually lead to cell death and to participate in the pathogenesis of many diseases. Autophagy, a process by which eukaryotic cells degrade and recycle macromolecules and organelles, plays an important role in the cellular response to oxidative stress. Here, we review the recent reports suggesting ROS of mitochondrial origin as signaling molecules in autophagy and its role in the pathogenesis.关键词
自吞噬作用/活性氧/线粒体/自噬性细胞死亡分类
医药卫生引用本文复制引用
尤寿江,石际俊,张艳林,刘春风..ROS介导的自噬及其在相关疾病中的作用[J].中国病理生理杂志,2011,27(1):187-190,195,5.基金项目
国家自然科学基金资助项目(No.30870869/C090301) （No.30870869/C090301）
