首页|期刊导航|中华医学杂志（英文版）|More questions than answers about the potential anticancer agents: DNA methylation inhibitors
中华医学杂志（英文版）2010，Vol.123Issue(9)：1206-1209,4.DOI:10.3760/cma.j.issn.0366-6999.2010.09.019
More questions than answers about the potential anticancer agents: DNA methylation inhibitors
More questions than answers about the potential anticancer agents: DNA methylation inhibitors
摘要
Abstract
Objective To review the emerging role of DNA methylation inhibitors in cancer therapy and make a serious reflection on their current status and future perspectives. Data sources The data used in the present article were mainly from PubMed with relevant English papers published from April 1988 to January 2010. The search terms were "DNA methylation", "demethylation" and "cancer". Study selection Studies involed in the DNA methylation in carcinogenesis and DNA methylation inhibitors for cancer therapy were selected. The original milestone articles were also included. Results Treatment with DNA methylation inhibitors leads to demethylation of a panel of tumour suppressor genes and reverse the expression in different tumors, thus making them potential cancer therapeutics. However, we cannot be very optimistic about their future perspectives because we still have a long way to go before they function well like specific targeted anticancer drugs as we expected.Conclusion The best way forward is to further clarify the exact methylation profiles of tumors and to develop novel agents targeting the specific genes.关键词
DNA methylation/demethylation/neoplasmsKey words
DNA methylation/demethylation/neoplasms引用本文复制引用
ZOU Xiao-ping,ZHANG Bin,LIU Ying..More questions than answers about the potential anticancer agents: DNA methylation inhibitors[J].中华医学杂志（英文版）,2010,123(9):1206-1209,4.基金项目
The project was supported by a grant from the Health Department Foundation of Jiangsu Province for Key Talents (No. RC2007003). （No. RC2007003）
