中国组织工程研究与临床康复2008，Vol.12Issue(53)：10567-10570,4.
同种异体单肺移植7例报告
Allogeneic single lung transplantation in 7 cases
刘德若 1张海涛 1梁朝阳 1王在永 1陈京宇 1鲍彤 1张真榕 1辛育龄 1郭永庆 1赵风瑞 1李福田 1葛炳生 1石彬 1田燕雏 1宋之乙 1寿延宁1
作者信息
- 1. 中日友好医院胸外科,北京市,100029
- 折叠
摘要
Abstract
The present case report was designed to summarize the clinical experience of operative technique. lung preservation, lung perfusion, and perioperative management. Of 7 cases who underwent allogenic single lung transplantation (LT), 3 were idiopathic pulmonary fibrosis, 2 were chronic obstructive pulmonary disease, 1 was silicosis, emphysema, and bulla, and I was tuberculosis in both sides and presented with destroyed lung in one side. All donors were already brain death. Donor lungs were well preserved utilizing Euro-Colins liquid or low-potassium dextran solution. Donors and recipients were matched in blood type. Of 7 cases selected,5 received single right lung transplantation, and 2 received single left LT. End-to-end anastomosis was performed for pulmonary branches and pulmonary arteries. while atrium-to-atrium anastomosis was performed for pulmonary vein. Antibiotics and immunosuppressants were routinely used prior to and subsequent to LT. Following LT, heart and lung function, usage of antibiotics, and adjustment of immunosuppressant were monitored. Stomal complications regarding bronchus and pulmonary artery and vein did not appear in any patient. Five cases survived for about 2 months, one for approximately 1 year, and one for nearly 2 years. Four cases died of multi-organ failure caused by pulmonary infection, and one of severe pulmonary hemorrhage caused by aspergillus sydowi infection. Rejection occurred in 6 cases. One case sufiered from rejection three times. Selection of indication, selection and preservafton of donor lung, LT operation and pre-and post-operative management of LT have acquired satisfactory achievements. High mortality occurred in patients with preoperative poor cardiac and pulmonary functions and postoperative severe infections accompany with application of immunosuppressant.关键词
肺移植/器官保存/并发症/器官移植Key words
Lung transplantation/lung preservation/complication/organ graft分类
医药卫生引用本文复制引用
刘德若,张海涛,梁朝阳,王在永,陈京宇,鲍彤,张真榕,辛育龄,郭永庆,赵风瑞,李福田,葛炳生,石彬,田燕雏,宋之乙,寿延宁..同种异体单肺移植7例报告[J].中国组织工程研究与临床康复,2008,12(53):10567-10570,4.
