生殖医学杂志2008，Vol.17Issue(z1)：38-44,7.DOI:10.3969/j.issn.1004-3845.2008.z1.008
Expression of glucose transporter 4 in endometrium of polycystic ovary syndrome
Expression of glucose transporter 4 in endometrium of polycystic ovary syndrome
Wang Wei 1Li Xiao-dong 2Hao Gui-min 1Xu Su-xin 1Cui Na 1Cao Jin-feng1
作者信息
- 1. Department of Reproduction,Second Hospital,Hebei Medical University,Shiji-azhuang,Hebei 050000,China
- 2. Department of Obstetrics & Gynecology,Second Hospital,Hebei Medical University,Shiji-azhuang,Hebei 050000,China
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摘要
Abstract
Objective:The aim of this study was to detect the expression of glucose transporter 4(GLUT4),insulin(INS)and insulin receptor(INS-R)genes and proteins in endometrium of patients with polycystic ovarian syndrome(P-COS)and control group and investigate the relationship between GLUT4 and insulin resistance(IR).Methods:The patients with PCOS were divided into two groups:hypertestosteronemia(h-T)group and hyperin-sulinemia(h-I)group.The expression of GLUT4,INS and INS-R genes and proteins in endometrium of PCOS groups and control group was detected by immunohistochemistry and reverse transcription-polymerase chain reaction.Results:There was the expression of GLUT4,INS and INS-R proteins and genes in endometrium of PCOS groups and control group.Compared with the control group,PCOS groups were significantly lower in the expres-sion of GLUT4 protein and gene as well as INS-R protein and gene but much stronger in the expression of INS pro-tein and gene.The GLUT4 gene expression in h-I group was lower than that of h-T group but the expression of INS protein in h-I group was siginificantly higher than that of h-T group.Conclusion:The expression of GLUT4,INS and INS-R in endometrium of PCOS and control groups is con-firmed.Hyperinsulinemia and hyperandrogen can cause the expression of GLUT4 to decrease.The decreased ex-pression of GLUT4 in PCOS may be related with the IR of endometrium.关键词
Polycystic ovarian syndrome/Endometium/Glucose transporter 4/Insulin/Insulin receptor/Insu-lin resistanceKey words
Polycystic ovarian syndrome/Endometium/Glucose transporter 4/Insulin/Insulin receptor/Insu-lin resistance引用本文复制引用
Wang Wei,Li Xiao-dong,Hao Gui-min,Xu Su-xin,Cui Na ,Cao Jin-feng..Expression of glucose transporter 4 in endometrium of polycystic ovary syndrome[J].生殖医学杂志,2008,17(z1):38-44,7.
