生殖医学杂志2008，Vol.17Issue(z1)：33-37,5.DOI:10.3969/j.issn.1004-3845.2008.z1.007
A study on lifestyle adjustment and insulin sensitizing treatment in PCOS-IR women
A study on lifestyle adjustment and insulin sensitizing treatment in PCOS-IR women
Ma Liang-kun 1Jin Li-na 1Yu Qi 1Xu Ling1
作者信息
- 1. Department of Obstetrics & Gynecology,Peking Union Medical College Hospital,Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing 100730,China
- 折叠
摘要
Abstract
Objective:To compare the efficacy of lifestyle adjustment,metformin and rosiglitazone on women with polycystic ovary syndrome and insulin resistance(PCOS-IR)Methods:A randomized controlled trial(RCT)was carried out in Peking Union Medical College Hospital(PUMCH),One hundred and six women with PCOS were randomly allocated to three intervention groups:lifestyle adjustment,lifestyle adjustment plus metformin,lifestyle adjustment plus rosiglitazone group,patients were treated with lifestyle adjustment(diet and exercise),lifestyle adjustment plus metformin(500mg three times daily),lifestyle adjustment plus rosiglitazone(4mg once daily)for three months.Sixty patients completed treatments,basal body temperature(BBT),total testosterone as well as fasting serum insulin and lipid levels were measured and compared in all patients before and after lifestyle adjustment.Results:No significant differences were found in the baseline characteristics among three groups.In lifestyle adjustment group 51%(22/43)patients completed treatment,23%(5/22)patients resumed ovulation.In lifestyle adjustment plus metformin group 58%(21/36)patients completed treatment,43%(9/21)patients resumed ovulation.In lifestyle adjustment plus rosiglitazone group 63%(17/27)patients completed treatment,59%(10/17)patients resumed ovulation.Ovulation rate was significantly higher in lifestyle adjustment plus rosiglitazone group than that in weight loss group.There was no significant difference among three groups in body mass index(BMI),waist circumference,waist-hip ratio(WHR),sex hormone,serum fasting insulin and lipid levels after treatment.Conclusions:Lifestyle adjustment,metformin and rosiglitazone treatment can improve ovulation each.关键词
Polycystic ovary syndrome/Lifestyle adjustment/Metformin/Thiazolidinediones/OvulationKey words
Polycystic ovary syndrome/Lifestyle adjustment/Metformin/Thiazolidinediones/Ovulation引用本文复制引用
Ma Liang-kun,Jin Li-na,Yu Qi,Xu Ling..A study on lifestyle adjustment and insulin sensitizing treatment in PCOS-IR women[J].生殖医学杂志,2008,17(z1):33-37,5.
