老年心脏病学杂志（英文版）2008，Vol.5Issue(3)：164-168,5.
Antiarrhythmic peptide AAPl0 prevents ventricular arrhythmia in rabbit LQT2 model
Antiarrhythmic peptide AAPl0 prevents ventricular arrhythmia in rabbit LQT2 model
Bodi Chen 1Liandong Li 1Lei Ruan 1Xiaoqing Quan 1Cuntai Zhang 1Jiagao Lu 1Rong Bai 1Nian Liu 1Yanfei Ruan 1Jun Ke 1Jin Ma1
作者信息
- 1. Department of Cardiology,Tongji Hospital Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China
- 折叠
摘要
Abstract
Background and Objective Increased transmural dispersion of repolarization (TDR) has been shown to contribute toinitiation and maintenance of ventricular arrhythmia in long QT syndromes(LQTS).Intercellular uncoupling through gap junctions isan important mechanism for maintaining TDR in both intact and diseased heart.The present study was to test the hypothesis thatimproving gap junction communication reduces TDR and prevents ventricular arrhythmia in rabbit LQT2 model.Methods Anarterially perfused rabbit left ventricular preparation and E-403 (0.5μmol/L)were used to establish a model of LQT2.Preparationswere randomly assigned to control(n=10),AAP-100nmol/L(n=10),AAP-500nM(n=10)groups.Transmural ECG as well as actionpotentials from both endocardium and epieardium was simultaneously recorded. Resuits In LQT2 model.presence of 500nmol/LAAP10 reduced endocardial action potential and TDR and prevented ventricular arrhythmia comparing with the control and AAP 100nmol/Lgroups(P＜0.05).Conclusions The presence of 500 nmol/LAAP10 reduces TDR and prevents ventricular arrhythmia in rabbitventricular model of LOT2.This study suggests a possible role of GJs in TDR in rabbit LQT2 model and indicates a new clinicalapproach to the management of LQTS.关键词
gap junction/long QT syndrome/transmural dispersion of repolarization/antiarrhythmic peptideKey words
gap junction/long QT syndrome/transmural dispersion of repolarization/antiarrhythmic peptide引用本文复制引用
Bodi Chen,Liandong Li,Lei Ruan,Xiaoqing Quan,Cuntai Zhang,Jiagao Lu,Rong Bai,Nian Liu,Yanfei Ruan,Jun Ke,Jin Ma..Antiarrhythmic peptide AAPl0 prevents ventricular arrhythmia in rabbit LQT2 model[J].老年心脏病学杂志（英文版）,2008,5(3):164-168,5.
