老年心脏病学杂志（英文版）2008，Vol.5Issue(4)：248-251,4.
Protective effects of trimetazidine against vascular endothelial cell injury induced by oxidation
Protective effects of trimetazidine against vascular endothelial cell injury induced by oxidation
Shenghu He 1Fengdi Yan 1Jing Zhan 1Jianfeng Yan 1Bin Yuan 1Shu Chen 1Yong Xie1
作者信息
- 1. Department of Cardiology,Subei Peoples Hospital of Jiangsu Province,Yangzhou 225001,China
- 折叠
摘要
Abstract
To explore the protective effects of trimetazidine on vascular endothelial cells injury induced by hydrogen peroxide (H2O2) and its pharmacological mechanisms of anti-oxidation.Methods Human umbilical vein endothelial cells (HUVECs) were injured by H2O2.Next,the cells were treated with three different concentrations of trimetazidine (1 μmol/L,10 μmol/L,100μmol/L,respectively).The viability of cells was detected by methyl thiazoeyl tetrazolium (MTT) assay.In addition,malondialdehyde (MDA)contents,superoxide dismutase (SOD) and secretion of NO were measured.Results Trimetazidine could enhance the viability of the injured HUVECs induced by oxidation,decrease the level of MDA,enhance the SOD activity,and increase the secretion of nitrogen monoxide.These effects were in a certain dose-dependent manner and the difference was significant among the three concentrations (P＜0.05).Conclusions Our results suggest that trimctazidine may protect lipid peroxidation and prevent oxidation-induced cellular dysfunction of HUVECs (J Geriatr Cardiol 2008;5:248-251)关键词
Trimctazidine/endothelial cells/oxidative damageKey words
Trimctazidine/endothelial cells/oxidative damage引用本文复制引用
Shenghu He,Fengdi Yan,Jing Zhan,Jianfeng Yan,Bin Yuan,Shu Chen,Yong Xie..Protective effects of trimetazidine against vascular endothelial cell injury induced by oxidation[J].老年心脏病学杂志（英文版）,2008,5(4):248-251,4.
