天然产物研究与开发2008，Vol.20Issue(6)：953-955,963,4.
螺卷毛壳霉代谢产物的抗菌活性研究
Antimicrobial Activity of the Epipolythiodioxopiperazines from Chaetomium cochliodes
摘要
Abstract
The in vitro antibacterial and antifungal activities of the epipolythiodioxopiperazines (1-5) isolated from Chaetomium cochliodes were evaluated using the cup-plate method for the first time. The structure-activity relationship (SAR) of compounds 1-5 was investigated. Compounds 1-5 exhibited a good activity profile versus Staphylococcus au-reus, and among them 1 showed the strongest activity. The SAR study of compounds 1-5 suggested that the disulfer bridge between C-3' and C-6'(1) is the active center for the antibacterial activity against S. aureus, and the S-S bridge between C-3 and C-11a(1,2 and 4) and the cyelization between N-6 and 0-3'(4 and 5) can enhance the activity.关键词
螺卷毛壳霉/抗细菌活性/抗真菌活性/构效关系Key words
Chaetomium cochloides/antibacterial/antifungal/structure-activity relationship分类
生物科学引用本文复制引用
杨恩超,杨涛,李宗珍,刘光烨,李国友..螺卷毛壳霉代谢产物的抗菌活性研究[J].天然产物研究与开发,2008,20(6):953-955,963,4.基金项目
This research was financially supported by the Knowl-edge Innovation Program of the Chinese Academy of Sciences. （）
