中国中西医结合杂志2011，Vol.31Issue(1)：19-22,4.
暖心胶囊治疗慢性心力衰竭的随机双盲对照研究
Double Blinded Randomized and Controlled Study on Treatment of Chronic Heart Failure by Nuanxin Capsule
摘要
Abstract
Objective To evaluate the effect and safety of Nuanxin Capsule (NXC) in treating patients with chronic heart failure (CHF). Methods Adopting the randomized, positive controlled, double-blinded design,150 CHF patients were assigned to the treatment group and the control group equally, they were treated with optimal westem medical therapeutic scheme in combining respectively with NXC and placebo for 24 weeks. The indices for effectiveness and safety evaluation, such as Chinese medicine syndrome, grade of heart function, myocardial contraction, as well as the re-hospitalization rate and mortality, were observed. Results The total effective rate on heart function in the treatment group and the control group was 78. 87％ and 64. 38％ respectively, that on Chinese medicine syndrome was 85.9％ and 63.0％ respectively, comparisons of the two indices between the two groups all showed significant difference ( P＜0.05, P＜0.01 ). And a better efficacy for improving patients' cardiac contraction function and quality of life was shown in the treatment group ( P＜0. 05, P＜0. 01 ). The re-hospitalization rates in them were 23.9％ and 53.4％ respectively ( P＜0.05), and 22. 54％ and 42. 5％ of the re-hospitalized patients had attack of acute heart failure, a significant difference was found between the two groups (P＜0. 05). The mortality in them was 2. 90％ and 8.95％ respectively, showing no significant difference between groups (P＞0. 05). No obvious adverse effect was found in both groups. Conclusions NXC could improve the heart function of patients, it has obvious curative effect and good safety in treating chronic heart failure.关键词
慢性心力衰竭/暖心胶囊/随机双盲设计引用本文复制引用
邹旭,潘光明,盛小刚,林晓忠,吴焕林,李松,尹克春,李健..暖心胶囊治疗慢性心力衰竭的随机双盲对照研究[J].中国中西医结合杂志,2011,31(1):19-22,4.基金项目
国家重点基础研究发展计划973计划资助项目(No.2005CB523502) （No.2005CB523502）
