中国普通外科杂志2011，Vol.20Issue(1)：11-14,4.
TNF-α和IL-2在肝移植急性排斥反应中的表达及意义
TNF-α and IL-2 expression and significance in acute rejection of liver transplantation
樊斌 1李德卫 1冯渊 1杨晓波1
作者信息
- 1. 重庆医科大学附属第一医院肝胆外科,重庆,400016
- 折叠
摘要
Abstract
Objective To investigate the expression of TNT-α and IL-2 in acute rejection of liver transplantation and evaluate their value as predictive indicators of acute rejection.Methods After orthotopic liver transplantation models was established in rats, real-time fluorescent quantitative reverse transcriptase polymerase chain reaction ( RT-PCR ) was used to detect the gene expression of TNF-α and IL-2 in the transplanted liver.The relationship between TNF-α/IL-2 expression and acute rejection was analyzed based on histopathologieal standard of acute rejection.Results On day 3,5 and 7 after transplantation, acute rejection occurred in the graft of all allogenic transplantation rats, and the mean levels of TNF-α and IL-2 in liver tissues were significantly higher in allogenic transplantation group than those in syngenic transplantation group.Conclusions TNF-α and IL-2 expression are related to the development of acute rejection after liver transplantation, and may be used as sensitive and reliable accessory indicators in detecting acute rejection.关键词
肝移植/TNF-α/IL-2/排斥反应分类
医药卫生引用本文复制引用
樊斌,李德卫,冯渊,杨晓波..TNF-α和IL-2在肝移植急性排斥反应中的表达及意义[J].中国普通外科杂志,2011,20(1):11-14,4.
