中国普通外科杂志2011，Vol.20Issue(1)：43-47,5.
HtrA1丝氨酸蛋白酶在原发性肝癌中的表达及其临床意义
Expression of HtrA1 serine protease in hepatocellular carcinoma and its clinical significance
金雷 1朱峰 2秦锡虎2
作者信息
- 1. 江苏大学附属武进医院,肝胆外科,江苏常州213002
- 2. 苏州大学附属第三医院(常州市第一人民医院)肝胆外科,江苏常州213003
- 折叠
摘要
Abstract
Objective To investigate the expression of HtrA1 serine protease in primary hepatocellular carcinoma( HCC ) tissue and its relationship with the tumor pathological characteristics. Methods HCC tissues and adjacent liver tissues was obtained from 37 hepatocellular carcinoma patients after hepatectomy. Expression levels of HtrAl serine protease mRNA were quantitatively analyzed by real-time PCR. Results HtrA1 mRNA in liver tumors was 1. 2729 ± 0. 9911 ,and HtrA1 mRNA in adjacent tissue was 3. 8667 ± 2. 8099. The HtrA1 mRNA in adjacent liver tissues were higher than those in hepatocellular carcinoma tissues (P = 0. 000 ). Multivariate Logistic regression analysis showed that the level of HtrAl mRNA, tumor metastasis and tumor capsule were the most important significantly independent factors for HCC venous invasion. Conclusions The expression of HtrA1 in HCC could be as an indicator of the prognosis, metastasis and recurrence.关键词
癌,肝细胞/HtrA1丝氨酸蛋白酶/实时荧光定最PCR分类
医药卫生引用本文复制引用
金雷,朱峰,秦锡虎..HtrA1丝氨酸蛋白酶在原发性肝癌中的表达及其临床意义[J].中国普通外科杂志,2011,20(1):43-47,5.
