中国普通外科杂志2011，Vol.20Issue(1)：62-66,5.
白术多糖对缺血再灌注损伤大鼠肝脏的保护作用
The protective effect of atractylodes macrocephalaon polysaccharide on hepatic ischemia reperfusion injury in rats
摘要
Abstract
Objective To investigate the protective effect of atractylodes macrocephalaon polysaccharide on ischemia-reperfusion(I/R) injury of liver in rats. Methods A total of 54 male SD rats were randomly divided into 3 groups: sham group, I/R group and preconditional treatment of atractylodes macrocephalaon polysaccharide group (Group PC ). The rats were killed at 1 , 6,24h after 60 mins of models conducted,and the serum ALT and AST level, the expression of ICAM-1 mRNA and IL-1 in liver tissue were observed.Results Compared with sham group, the ALT and AST levels, the expression of ICAM-1 mRNA and IL-1 were significantly increased in PC and I/R groups, but compared to I/R group, the ALT and AST levels and the expression of ICAM-1 mRNA and IL-1 in PC group were significantly decreased ( P ＜ 0. 05 ).Conclusions Atractylodes macrocephalaon polysaccharide may have protection to ischemic injury of rat liver through reduction of ICAM-1 expression and decrease production of IL-1.关键词
再灌注损伤/肝/白术多糖/治疗应用/大鼠分类
医药卫生引用本文复制引用
张培建,张杰,卜平,刘歆农,苏辉,孟中良,庄卓男,伍学艳..白术多糖对缺血再灌注损伤大鼠肝脏的保护作用[J].中国普通外科杂志,2011,20(1):62-66,5.基金项目
江苏省卫生厅面上科研课题(H200770) （H200770）
江苏省中医药科技项目(LZ09133). （LZ09133）
