国际医药卫生导报2011，Vol.17Issue(4)：439-442,4.DOI:10.3760/cma.j.issn.1007-1245.2011.04.022
围术期输注羟乙基淀粉和琥珀酰明胶对老年患者肾功能的影响
Compare the influence of succinylated gelatin and hydroxyethyl starch on renal function in the elderly during perioperative period
谭秀华 1黄隽 1卢筱琳 1陈戟 1詹鸿1
作者信息
- 1. 510150,广州,广州医学院第三附属医院麻醉科
- 折叠
摘要
Abstract
Objective To compare the influence of succinylated gelatin and hydroxyethyl starch(130/0.4) on renal function in the elderly during perioperative period. Methods Forty patients undering breast operation and thyroid operation were randomly equally divided into G group and V group. 20starch; and supplemented the rest essential liquid with acetated Ringer's solution. On the first and second postoperative day, the same Gelofusine was infused in G group, and the V group with the same hydroxyethyl starch. HR, MAP, CVP, serum creatinine(Cr), hematological α 1-microglobulin, urinary α1-microglobulin and retinol-binding protein(RBP) were measured before anesthesia(T0), at the end of operation(T1), 5 hours after operation(T2), on the first(T3), second(T4) and third(Ts) postoperative day. Results Vital sign and Cr were normal in both groups. The level of hematological α1-microglobulin was higher than normal, but had no significant difference between G group and V group. The level of urinary α1-microglobulin and retinolbinding protein(RBP) in both groups increased significantly at T2 ～ T5 as compared with T1; and the level of these two parameters in V group were significantly higher than G group at T2 ～ T5. Conclusion This study show that, compare with succinylated gelatin, hydroxyethyl starch has more influence on renal function, especially on renal tubule, in the elderly.关键词
琥珀酰明胶/羟乙基淀粉/肾功能/老年人Key words
Succinylated gelatin/hydroxyethyl starch/Renal function/The elderly引用本文复制引用
谭秀华,黄隽,卢筱琳,陈戟,詹鸿..围术期输注羟乙基淀粉和琥珀酰明胶对老年患者肾功能的影响[J].国际医药卫生导报,2011,17(4):439-442,4.
