国际医药卫生导报2011，Vol.17Issue(4)：455-459,5.DOI:10.3760/cma.j.issn.1007-1245.2011.04.028
固相萃取-高效液相色谱法测定人血浆中雷尼替丁浓度
Dertermination of Ranitidine in Human Plasma by Solid phase Extraction and HPLC
薛晓燕 1朱荣华 2彭文兴 2李焕德2
作者信息
- 1. 511700,东莞市石龙人民医院药剂科
- 2. 410011,中南大学湘雅二医院临床药学研究室
- 折叠
摘要
Abstract
Objective To make a sensitive method for the determination of ranitidine in human plasma by HPLC-UC. Methods Plasma samples were extracted with C18 Solid phase columns. Chromatograph analysis was carried out with a C18 column and UV Detector which was set at 316 nm. Results Interior impurity in human plasma does not interfere with the determination of ranitidine and internal standard. Good linear relationship(r2=0.999) was obtained in the concentration range from 10.0 to 1000.02%. Conclusion This method is sensitive, selective and simple, is suitable for clinical pharmacokinetic and bioequivalent study of ranitidine.关键词
雷尼替丁/HPLC-UV/血浆/药动学Key words
Ranitidine/HPLC-UV/Bioequivalent引用本文复制引用
薛晓燕,朱荣华,彭文兴,李焕德..固相萃取-高效液相色谱法测定人血浆中雷尼替丁浓度 [J].国际医药卫生导报,2011,17(4):455-459,5.
