中山大学学报（自然科学版）2011，Vol.50Issue(1)：79-84,6.
环丙沙星氯化反应的转化产物及机理研究
Investigation on the Reaction of Ciprofloxacin and Chlorine
摘要
Abstract
In the present study, the reaction of ciprofloxacin with free available chlorine was investigated.The reaction products were concentrated and isolated by solid phase column and analyzed by Mass Spectrometry and NMR.Five products were identified, in which monochloro- and dichloro-quinolones were the major compounds.Mass fragment pathways of identified products were also elucidated.Chlorination reaction center concentrated on the position C3 and C8 of the quinolone ring.Besides of chlorination, the piperazine ring on the position C7 of the quinolone ring was broken to form amine.The side chain alkylamine was further de-alkylation and hydroxylation.关键词
环丙沙星/氯化产物/质谱/结构表征分类
化学化工引用本文复制引用
周海云,欧阳群香,彭敏芝,李维..环丙沙星氯化反应的转化产物及机理研究[J].中山大学学报（自然科学版）,2011,50(1):79-84,6.基金项目
教育部CERS资助项目 （）
广州地区分析测试基金专题资助项目 （）
