浙江医学2011，Vol.33Issue(2)：161-163,3.
炎症因子及血管内超声检查对冠心病患者预后的评估作用
Prognostic value of plasma inflammatory factors and coronary arterial culprit lesions in patients with coronary artery disease
摘要
Abstract
Objective To investigate the prognosis value of inflammation factors and coronary lesion characteristics in patients with coronary artery disease (CHD). Methods Eighty nine patients with acute coronary syndrome (ACS)and 72 patients with stable angina (SA) were enrolled in the study. Coronary lesion characteristics were examined by intravascular ultrasound (IVUS) before percutaneous coronary intervention. Plasma concentrations of high sensitive C-reaction protein (hs-CRP) and Pro- matrix metalloproteinase- 1 (ProMMP- 1) were measured by enzyme linked immunosorbent assay. Patients were followed 1 year for subsequent major adverse cardiac events (MACE). Events were defined as death, myocardial infarction, and any revascularization. Results Patients with ACS had increased external elastic membrane cross-sectional area (EEM CSA), plaque burden, lipid pool burden. smaller minimal lumen cross- sectional area, thinner fibrous- cap compared with those with SA; ruptured and vulnerable plaques, positive remolding and thrombus were more frequently observed in ACS patients (P＜0.05 or 0.01). The level of plasma hs- CRP and proMMP-1 were higher in patients with ACS (P＜0.05 or 0.01). Strong associations were found between hs-CRP and EEM CSA, plaque burden, lipid pool burden and the type of the plaque (P＜0.05 or 0.01), while only the type of the plaque had the association with proMMP-1 (P＜0.01). Smoking, high density lipoprotein, hs- CRP and troponin Ⅰwere independently associated with MACE(P＜0.05 or 0.01). Conclusion There is a strong association between hs-CRP and the vulnerability of plaque. hs-CRP is an independent risk factor for MACE and can be used for evaluation of the prognosis of patients with CHD combined with correlated coronary arterial culprit lesions of IVUS.关键词
冠状动脉疾病/超敏C反应蛋白/血管内超声/主要心脏不良事件引用本文复制引用
杨建敏,童国新,张邢炜,王宁夫,高炎,李佩璋,周亮,叶显华,徐坚,潘浩..炎症因子及血管内超声检查对冠心病患者预后的评估作用[J].浙江医学,2011,33(2):161-163,3.基金项目
浙江省卫生厅科研项目(2004A075) （2004A075）
杭州市科技局重点专科项目(2004433Q06) （2004433Q06）
