北京师范大学学报（自然科学版）2011，Vol.47Issue(1)：49-53,5.
18F正电子药物自动化合成装置BNU F-A2的研制及应用
DEVELOPMENT AND APPLICATION OF AUTOSYNTHESIZERS BNU F-A2 FOR RADIOPHARMACEUTICALS LABELED WITH 18F
摘要
Abstract
BNU F-A2, an auto-synthesizer, for radiopharmaceutical labelling with 18F, has been developed, which can implement multiple chemical processes such as drying, fluoridation, purification, and can be used to synthesize multiple radiopharmaceuticals labeled with 18F. Compared with already commercialized auto-synthesizers, BNU F-A2 is multifunctional, more appropriate and inexpensive for use in research. For hardware, up to 9 solutions can be loaded in separate vials, and be controlled by solenoid valves. Reaction time and temperature can be setup with a large range. For software, modular programming is used to separate the chemical processes into serial steps. The auto-synthesizer can be controlled manually, be wireless controlled, or operated by a workstation either automatically or step-by-step. [18F]FMISO and [18F]FET were synthesized using this auto-synthesizer. Such pilot studies indicated that BNU F-A2 was flexible hardwarewise, and friendly softwarewise. It is a powerful and efficient instrument for research and exploitation of radiopharmaceuticals.关键词
自动化合成装置/18F/正电子药物/多功能性/自动化Key words
auto-synthesizers/ 18F/ radiopharrnaceuticals/ multifunctional/ automatic引用本文复制引用
乔洪文,李崧,刘亚静,浮吉生,刘正浩,孙继壮,朱霖..18F正电子药物自动化合成装置BNU F-A2的研制及应用[J].北京师范大学学报（自然科学版）,2011,47(1):49-53,5.基金项目
国家"973"资助项目(2006CB500705) （2006CB500705）
国家"863"计划资助项目(2006AA02Z184) （2006AA02Z184）
