动物学研究2011，Vol.32Issue(1)：62-65,4.DOI:10.3724/SP.J.1141.2011.01062
精神分裂症易感基因DKK4与中国人群大脑容量的相关性
Association of the schizophrenia susceptible gene DKK4 with brain volume in Chinese populations
张丽红 1李明 2施晓东 3任惠 4宿兵 1徐忠2
作者信息
- 1. 昆明医学院第一附属医院,干部医疗科,云南昆明,650031
- 2. 中国科学院昆明动物研究所,遗传资源与进化国家重点实验室,云南昆明,650223
- 3. 中国科学院研究生院,北京,100049
- 4. 曲靖师范学院,生物资源与环境科学学院,云南曲靖,655011
- 折叠
摘要
Abstract
Schizophrenia is one of the most severe mental disorders with a worldwide incidence of 1％. Previous studies suggested that the brain volumes of the schizophrenia patients were much smaller than the healthy individuals and many schizophrenia susceptible genetic variants have been shown associated with structural brain abnormalities in patients, which is consistent with the neurodevelopmental hypothesis of the etiology of schizophrenia. Recently, the DKK4 gene involved in the Wnt signaling was found to be significantly associated with schizophrenia. To test whether DKK4 is associated with neurodevelopment, we genotyped one DKK4 SNP in 961 healthy Chinese individuals and measured their brain volumes. We found that the SNP was significantly associated with brain volume under both additive and dominant genetic models, providing evidence that schizophrenia susceptible genes could influence brain volume. Our findings support the neurodevelopmental hypothesis of the etiology of schizophrema.关键词
精神分裂症/脑容量/DKK4/单核苷酸多态性分类
生物科学引用本文复制引用
张丽红,李明,施晓东,任惠,宿兵,徐忠..精神分裂症易感基因DKK4与中国人群大脑容量的相关性[J].动物学研究,2011,32(1):62-65,4.
