动物学研究2011，Vol.32Issue(1)：70-80,11.DOI:10.3724/SP.J.1141.2011.01070
非人灵长类肿瘤模型研究进展
Progress of non-human primate animal models of cancers
摘要
Abstract
Cancer is the second leading disease causing human death. Pre-clinical in vivo studies are essential for translating in vitro laboratory research results into the clinic. Rodents, including the mouse and rat, have been widely used for pre-clinical studies due to their small size, clear genetic backgrounds, rapid propagation, and mature transgenic technologies. However, because rodents are evolutionarily distinct from humans, many pre-clinical research results using rodent models cannot be reproduced in the clinic. Non-human primates (NHPs) may be better animal models than rodents for human cancer research because NHPs and humans share greater similarity in regards to their genetic evolution, immune system, physiology and metabolism. This article reviews the latest progress of cancer research in NHPs by focusing on the carcinogenesis of different NHPs induced by chemical and biological carcinogens. finally, future research directions for the use of NHPs in cancer research are discussed.关键词
非人灵长类/肿瘤/树鼩Key words
Non-human primate/ Cancer/ Tree shrew分类
医药卫生引用本文复制引用
夏厚军,陈策实..非人灵长类肿瘤模型研究进展[J].动物学研究,2011,32(1):70-80,11.基金项目
This work was supported in part by a grant from Yunnan Province High-Profile Talent Project(云南省高端人才计划 2010CI114),and grants from Chinese Academy of Sciences(Basic frontier project,KSCX2-EW-J-23) （云南省高端人才计划 2010CI114）
