动物学研究2011，Vol.32Issue(1)：11-16,6.DOI:10.3724/SP.J.1141.2011.01011
中缅树鼩自然感染六种病毒的血清流行病学
Sero-epidemiology of six viruses natural infection in Tupaia belangeri chinensis
摘要
Abstract
Tupaia (Tupaia belangeris chinensis, tree shrew) as a new experiment animal in medicine are non-rodent,small animals and close to primates in evolution. Experimental animals infected with viruses will affect the animal's health, interference experiment, and even endanger the operator's safety. Therefore, the viral infection in experimental animals has long been considered an important part of quality control. Lack of clearer viral natural infection information on the T. belangeris limits its use. Six viruses infection in 272 wild capture and artificial breeding Tupaia were investigated inthis study. All serum samples were detected for the hepatitis B virus surface antigen, the total antibodies of HCV, hepatitis E virus (HEV), adenovirus (ADV), herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2) by ELISA. The results showed that anti-HCV antibody and anti-HEV, ADV, HSV-1 IgG antibodies were negative, only one sample was positive of anti-HSV-2 IgG. Three samples were positive in the primary ELISA detection of HBV surface antigen, but two pairs of semi-quantitative detection of hepatitis B and further recognized as negative.The results implied that antigen or antibody-positive results appeared in the hepatitis serological test is not accurate enough and confirmation by other virological indicators is necessary. Tupaia breeding herd should be screened for HSV-2 in order to prevent and control the virus infection.关键词
中缅树鼩/树鼩/自然感染/病毒/血清/流行病学Key words
Tree shrew/ Tupaia/ Natural infection/ Virus/ Serum/ Epidemiology分类
生物科学引用本文复制引用
韩建保,张高红,段勇,马建平,张喜鹤,罗荣华,吕龙宝,郑永唐..中缅树鼩自然感染六种病毒的血清流行病学[J].动物学研究,2011,32(1):11-16,6.基金项目
中国科学院基础前沿研究专项项目(KSCX2-EW-J-23) （KSCX2-EW-J-23）
中国科学院和云南省动物模型与人类疾病机理重点实验室资助项目 （）
