北京生物医学工程2011，Vol.30Issue(1)：32-38,7.DOI:10.3969/j.issn.1002-3208.2011.01.07
凝血瀑布机制中蛋白C作用的动力学模型研究
Dynamic Model Analysis of Protein C in Blood Coagulation Mechanism
摘要
Abstract
In the process of blood coagulation, a serial reaction of protein factors is involved. The active protein on the first level decomposes the subordinate protein, that causes the subordinate protein to become the active protein, and causes the response to continue forming the response waterfall mechanism. During the essential process of feed back reaction about blood coagulation, protein C plays an important role. This article investigates the effect of protein C on factor V and whole blood coagulation system during the beingactivated and being-deactivated processes of blood coagulation. Based on the physiological experiment, a nonlinear mathematic model of blood coagulation cascade was put forward. According to the fixed point theory, stability analysis was completed. We approved that there was a threshold value in the extrinsic blood coagulation cascade. We simulated numerically and found the effect of protein C on the whole blood coagulation. It was indicated that lack of protein C little affect the whole blood coagulation. Whether protein C was lack or not did not influence the threshold value of initiated stage of blood coagulation. However when the concentration of protein C was excessive, the concentration of Ⅱa reduced to zero along with time going, that indicated whole system could not be initiated normally and influence of protein C to Ⅱa was very strong. These results above provide kind of beneficial enlightenment to the hematology theory and clinical research, also show the modeling method is useful and available for providing beneficial help to the blood coagulation studies.关键词
凝血机制/动力系统/稳定性分析/蛋白C/数值模拟分类
医药卫生引用本文复制引用
许传青,宫雷,杜键,袁德辉,王素云,曾衍钧..凝血瀑布机制中蛋白C作用的动力学模型研究[J].北京生物医学工程,2011,30(1):32-38,7.基金项目
国家自然科学基金(30800244)、广东省教育厅自然科学基金(04J012)资助 （30800244）
