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Mismatch repair, minichromosome maintenance complex component 2, cyclin A, and transforming growth factor β receptor type Ⅱ as prognostic factors for colorectal cancer: results of a 10-year prospective study using tissue microarray analysis

ZHAO Dong-bing Ian Chandler CHEN Zheng-ming PAN Hong-chao Sanjay Popat SHAO Yong-fu Richard S Houlston

中华医学杂志（英文版）2011，Vol.124Issue(4)：483-490,8.

中华医学杂志（英文版）2011，Vol.124Issue(4)：483-490,8.DOI:10.3760/cma.j.issn.0366-6999.2011.04.001

Mismatch repair, minichromosome maintenance complex component 2, cyclin A, and transforming growth factor β receptor type Ⅱ as prognostic factors for colorectal cancer: results of a 10-year prospective study using tissue microarray analysis

ZHAO Dong-bing ¹Ian Chandler ²CHEN Zheng-ming ³PAN Hong-chao ³Sanjay Popat ⁴SHAO Yong-fu ⁴Richard S Houlston³

作者信息

1. Department of Abdominal Surgical Oncology, Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
2. Department of Cellular Pathology, St George's Hospital, London,SW170QT, UK
3. Section of Cancer Genetics, Institute of Cancer Research, Sutton,SM2 5NG, UK
4. Clinical Trial Service Unit, Richard Doll Building, Old Road Campus,Roosevelt Drive, Oxford, OX3 7LF, UK
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摘要

Abstract

Background The expression of genes encoding a number of pathogenetic pathways involved in colorectal cancer could potentially act as prognostic markers. Large prospective studies are required to establish their relevance to disease prognosis.Methods We investigated the relevance of 19 markers in 790 patients enrolled in a large randomised trial of 5-fluorouracil using immunohistochemistry and chromogenic in situ hybridisation. The relationship between overall 10-year survival and marker status was assessed.Results Minichromosome maintenance complex component 2 (MCM2) and cyclin A were significantly associated with overall survival. Elevated MCM2 expression was associated with a better prognosis (HR=0.63, 95%CI: 0.46-0.86).Cyclin A expression above the median predicted an improved patient prognosis (HR=0.71, 95%CI: 0.53-0.95). For mismatch repair deficiency and transforming growth factor β receptor type Ⅱ (TGFBRII) overexpression there was a borderline association with a poorer prognosis (HR=0.69, 95%C/: 0.46-1.04 and HR=2.11, 95%CI: 1.02-4.40,respectively). No apparent associations were found for other markers.Conclusion This study identified cell proliferation and cyclin A expression as prognostic indicators of patient outcome in colorectal cancer.

关键词

colorectal cancer/tissue microarray/immunohistochemistry/prognostic markers

Key words

colorectal cancer/tissue microarray/immunohistochemistry/prognostic markers

引用本文复制引用

ZHAO Dong-bing,Ian Chandler,CHEN Zheng-ming,PAN Hong-chao,Sanjay Popat,SHAO Yong-fu,Richard S Houlston..Mismatch repair, minichromosome maintenance complex component 2, cyclin A, and transforming growth factor β receptor type Ⅱ as prognostic factors for colorectal cancer: results of a 10-year prospective study using tissue microarray analysis[J].中华医学杂志（英文版）,2011,124(4):483-490,8.

基金项目

This work was supported by grants from Cancer Research UK and the Association for International Cancer Research. Ian Chandler was in receipt of a Clinical Research Fellowship grant from St.George's Hospital Charitable Foundation Medical Research Committee. （）

中华医学杂志（英文版）

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ISSN：0366-6999

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