山西医科大学学报2011，Vol.42Issue(1)：37-41,5.DOI:10.3969/J.ISSN.1007-6611.2011.01.010
尼纶线、薇荞线对缝合部位皮肤衰老因子影响的实验研究
Experimental study for comparing the effects of nylon line and vicryl line on the skin aging factors on the operation area
马恬 1贾赤宇 2张辉 3徐凯3
作者信息
- 1. 军医进修学院,北京,100853
- 2. 中国人民解放军第309医院整形美容烧伤修复中心科
- 3. 山西医科大学第二临床医学院
- 折叠
摘要
Abstract
Objective To explore a better clinical surgical suture by comparing the effect of nylon line and vicryl line on the skin aging on the operation area. Methods Twenty aging rabbits were randomly divided into 2 groups nnylon group and vicryl group. Two different kinds of lines were implanted under the skin of rabbits at day 1 ,30,45 ,60 , 75 , 83 , 87 , respectively. At day 90 , skin samples from surgical areas were cut and divided irUo two pafls in two goups. One part of samples was used to determine total antioxidant capacity ( T AOC) ,superoxide dismutase ( SOD) activity. the contents of hydrogen peroxide ( H202 ) and hydroxyproline( HYP) in aging skins,while the other part was used to observe the skin histopathological changes on the operation area. Results The total antioxidanc capacity,the superoxide dismutase capacity.and the hydroxyproline content in vicryl group were significantly higher than those in nylon group( P ＜ 0. 05 ) . The level of hydrogen peroxide was significantly lower in vicryl group than that in nylon group( P＜ 0. 05 ) . Conclusion Compared with the nylon line,rhe vicryl line can delay the skin aging hy increasing the total antioxidant capacity and superoxide dismutase. activity and decreasing the hydrogen peroxide in the implantation site. Compared wiLh the nylon line, the vicryl line may be more favorable for wound healing by regulating the expression of skin aging factors in the operation region.关键词
外科缝线/羟脯氨酸/超氧化物歧化酶/衰老分类
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马恬,贾赤宇,张辉,徐凯..尼纶线、薇荞线对缝合部位皮肤衰老因子影响的实验研究 [J].山西医科大学学报,2011,42(1):37-41,5.
