武警医学2011，Vol.22Issue(1)：27-29,33,4.
天然化合物TTS-12对白念珠菌细胞凋亡的影响
The effect of TTS-12 on apoptosis of Candida albicans
摘要
Abstract
Objective To study the effect of the natural compound TIS - 12 on apoptosis of Candida albicans.Methods The morphological changes in the cells treated with TTS - 12 were shown by transmission electron micrography.The apoptosis rate was determined using annexin V and PI.Reactive oxygen species (ROS) was detected on the POLAR star Galaxy.Results TTS - 12 significantly induced C.albicans apoptosis, compared with the control group.The apoptosis rate of C.albicans was 58％ at TTS - 12 concentrations of 8 μg/ml.Compared with normal cells, the apoptotic cells induced by TTS - 12 showed increased endogenous ROS generation in a dose - dependent and time - dependent manner.Conclusion TTS - 12 induces Candida albicans apoptosis by enhancing endogenous ROS generation.关键词
TTS-12/白念珠菌/凋亡/活性氧分类
医药卫生引用本文复制引用
黄杉,曹颖瑛,姜远英..天然化合物TTS-12对白念珠菌细胞凋亡的影响[J].武警医学,2011,22(1):27-29,33,4.基金项目
国家自然科学基金(30630071,30870105). （30630071,30870105）
