福建农林大学学报（自然科学版）2011，Vol.40Issue(1)：64-68,5.
硫酸新霉素在奥尼罗非鱼体内的药代动力学及残留研究
Pharmacokinetics and residues of neomycin sulfate in hybrid tilapia ( Oreochromis aureus × O. niloticus )
摘要
Abstract
The metabolism and elimination of neomycin sulfate (NS) in hybrid tilapia ( Oreochromis aureus × O. niloticus ) was studied with the hybrid tilapia of 150 mg · kg-2 by single oral administration at (25 ±2) ℃. The results were as follows: plasma concentration and time dats of NS fitted with a two-compartmental open model. Absorption, distribution and elimination half-life were 1.05、2.05、11.94 h, respectively. The maximal plasma concentration was 7.013 μg · mL-1, peaking time was 2.856 h after dosing. The area under the curve of plasma drug concentration and time was 101.22 μg · h · mL-1. Muscle was selected as target tissue in this experiment. Because of the maximum residue limit (MRL) of European was 500 μg · kg-1 in muscle, the withdrawal time was suggested not to be less than 7 days under this experiment condition.关键词
硫酸新霉素/奥尼罗非鱼/药代动力学/残留Key words
neomycin sulfate/ hybrid tilapia/ pharmacokinetics/ residue分类
农业科技引用本文复制引用
廖碧钗,樊海平,林丽聪,余培建..硫酸新霉素在奥尼罗非鱼体内的药代动力学及残留研究[J].福建农林大学学报（自然科学版）,2011,40(1):64-68,5.基金项目
农生公益性行业专项资助项目(200803013). （200803013）
