肝胆胰外科杂志2011，Vol.23Issue(1)：4-6,3.
白术多糖预处理对大鼠肝脏缺血再灌注损伤后肝细胞线粒体结构的影响
Effect of atractylodes macrocephalaon polysaccharide pre-disposal treatment after ischemia reperfusion injury of liver on the chondriosome structure of hepatic cell in rats
摘要
Abstract
Objective To investigate the effect of atractyiodes macrocephalaon polysaccharide pre-disposal treatment after ischemia reperfusion injury of liver on the chondriosome structure of hepatic cell in rats.Methods Fifty-four male SD rats were randomly divided into 3 groups: Sham group, ischemia-reperfusion group (HIRI group) and pre-disposal treatment of atractylodes macrocephalaon polysaccharide group (AMP group), the rats were killed at 1, 6 and 24 h after 60 min ischemia-reperfusion, the changes of ultramicrostructure of hepatic cell were investigated, then the changes of diameters, perimeters and areas of chondrosomes were quantitatively analyzed. Results Cellular nucleus shrinkage deformity, chromatin asperity, nucleole concentration even spallation, rupture of membrane, crista mitochondriales rarias and dissolve were seen in HIRI group under transmission electron microscope, the hepatic cell of AMP group were improved obviously; the diameters, perimeters and areas of chondrosomes were quantitatively analyzed in AMP group, they were much smaller compared with HIRI group (P＜0.05), the degree of injury was lightened. Conclusion Atractylodes macrocephalaon polysaccharide has an obviously protection of hepatic cell chondriosome from injury caused by hepatic ischemia reperfusion injury.关键词
肝脏/缺血再灌注损伤/线粒体/白术多糖/大鼠Key words
liver/ ischemia reperfusion injury/ chondriosome/ atractylodes macrocephalaon polysaccharide/rats分类
医药卫生引用本文复制引用
张杰,刘歆农,张培建,苏辉,郎洁,庄卓男,孟中良,伍学艳..白术多糖预处理对大鼠肝脏缺血再灌注损伤后肝细胞线粒体结构的影响[J].肝胆胰外科杂志,2011,23(1):4-6,3.基金项目
江苏省卫生厅面上科研课题(H200770) （H200770）
江苏省中医药科技项目(LZ09133). （LZ09133）
