高等学校化学学报2011，Vol.32Issue(1)：79-83,5.
α-取代苯乙酰胺类化合物的合成及生物活性
Syntheses and Biological Activities of α-Substitued Phenylethyl Amide Compounds
摘要
Abstract
Mandipropamid is the first mandelamide fungicide on the market. Two series of novel N-substitued benzyloxy-α-alkoxy phenylacetamide compounds and α-subsitued benzylamino-phenylacetamide compounds,the bioisosteric analogues of Mandipropamid, were synthesized from vanillin and mandelic acid by substitution, reduction and so on. Their structures were characterized and determined by 1H NMR and HRMS. The results of the preliminary biological activity tests show that some of the compounds exhibite some anti-fungal activities. For example, N-( 3-methoxyl-4-ethoxylbenzyloxy)-α-ethoxyl-4-chloride-phenylacetamide have an inhibition rate of 90％ against cucumber downy mildew at the concentration of 200 μg/mL. N-(3-Methoxyl-4ethoxylbenzyloxy)-α-isopropoxy-4-chloride-phenylacetamide has an inhibition rate of 80％ against phytophthora capsici at the concentration of 20 μg/mL.关键词
苯乙酰胺/扁桃酰胺/杀菌活性Key words
Phenylacetamide/ Mandelamide/ Anti-fungal activity分类
化学化工引用本文复制引用
李欢欢,王振军,王力钟,李正名,赵卫光..α-取代苯乙酰胺类化合物的合成及生物活性[J].高等学校化学学报,2011,32(1):79-83,5.基金项目
国家"九七三"计划项目(批准号:2010CB126105)、国家科技支撑计划项目(批准号:2011BAE06805-3)和国家自然科学基金(批准号:20772069)资助. （批准号:2010CB126105）
