河北医学2011，Vol.17Issue(1)：51-54,4.DOI:10.3969/j.issn.1006-6233.2011.01.018
血管生成抑制剂联合分化诱导剂治疗结肠癌肝脏转移的实验研究
Experimental Study of the Therapy Effects of Angiogenesis Inhibitor and Differentiation Inducer on Human Colon Cancer
邢会军 1崔秀成 1侯雷 1刘志满1
作者信息
- 1. 承德医学院附属医院肿瘤一科,河北承德,067000
- 折叠
摘要
Abstract
To study the anti-cancer metastasis effects of angiogenesis inhibitor TNP-470 combined with differention inducer RA by human colon cancer liver metastasis into nude mice. Method:Liver metastases tumor into nude mice with colon cancer of LOVO cell was established. The nude mice were divided into 4 groups at random. Treated respectively from one day after implanted and metastased, all the nude mice were sacrificed by the end of treatment, then observed the liver metastasis rate and tumor foci as well as expression of VEGF in the liver metastatic tumors wer counted. Result: TNP-470 in combination with RA and TNP-470 alone display a significant inhibitory effect on liver metastasis compared to that of the control group ( P＜O. 05 ), the combination group was different from RA group on liver metastasis ( P＜0.05 ).The expression of VEGF in the liver metastasis tumors was clearly inhibited by TNP-470 in combination with RA and RA alone compared to that of the control ( P＜0.05 ). Conclusion: The angiogenesis inhibitor TNP470 in combination with differention inducer RA might has additive effect on the liver metastasis in nude mice. RA also could inhibit carcinoma cell proliferation by inducing apoptosis of colon cancer cell, inhibiting expression of VEGF.关键词
结肠癌/血管生成抑制剂TNP-470/分化诱导剂RA/裸鼠模型Key words
Colon cancer/ Angiogenesis inhibitor TNP-470/ Differention inducer RA/ Nude mice model引用本文复制引用
邢会军,崔秀成,侯雷,刘志满..血管生成抑制剂联合分化诱导剂治疗结肠癌肝脏转移的实验研究[J].河北医学,2011,17(1):51-54,4.
