广东药学院学报2011，Vol.27Issue(1)：14-17,4.DOI:10.3969/j.issn.1006-8783.2011.01.004
司坦唑醇分散片处方及制备工艺研究
Optimization of the formula and preparation technology of stanozolol dispersible tablets
蒋掬月 1周明礼 1韦笑 1陆东 1刘雪原1
作者信息
- 1. 广西南宁百会药业集团有限公司,广西,南宁,530003
- 折叠
摘要
Abstract
Objective To investigate the formula and preparation technology of stanozolol dispersible tablets.Methods Preliminary experiments were designed to screen the formula, which was optimized by the orthogonal test,and the effect of particle size on drug dissolution was examined. Results The optimized formula for stanozolol dispersible tablets ( in per 1 000 tablets) were as follows: 180 g lactose as filling agent,10 g CMS-Na as inner-disintegrant,5％ (w) CMS-Na as adhesive, 2％ (w) CMS-Na and 3％ (w)MCC for weight of dry particles as outer-disintegrants, and 1％ magnesium stearate as lubricant.Conclusion The prepared stanozolol dispersible tablets is reasonable in formula , feasible in technology and it is suitable for industrial production.关键词
司坦唑醇/分散片/处方工艺分类
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蒋掬月,周明礼,韦笑,陆东,刘雪原..司坦唑醇分散片处方及制备工艺研究[J].广东药学院学报,2011,27(1):14-17,4.
