广东药学院学报2011，Vol.27Issue(1)：91-93,3.DOI:10.3969/j.issn.1006-8783.2011.01.023
广东人群药物代谢酶CYP2C9基因A895G位点多态性研究
The study on the polymorphism of A895G of drug metabolizing enzyme CYP2C9 gene in Guangdong population
摘要
Abstract
Objective To investigate the polymorphism of A895G in exon 6 of CYP2C9 gene in Guangdong population. Methods The DNA fragments spanning the loci A895G in exon 6 of CYP2C9 gene were amplified by polymerase chain reaction , the PCR products were subjected to VpaK11BI digestion , then the genotypes were determined with polyacrylamide gel electrophoresis ( PAGE) and sliver-staining. Results Three individuals were heterozygotes ( A895/G895) in 252 individuals studied, others were wild-type homozygotes. Conclusion There was CYP2C9 895G namely CYP2C9 * 16 allele in Guangdong population ,whose frequency was 0. 006. This study has provided some reference for the appropriate usage of drugs metabolized by CYP2C9.关键词
药物代谢酶/CYP2C9/多态性/广东人群分类
生物学引用本文复制引用
何震宇,黄国庆,潘伟,崔炳权,杨红..广东人群药物代谢酶CYP2C9基因A895G位点多态性研究[J].广东药学院学报,2011,27(1):91-93,3.基金项目
广东省自然科学基金(034051) （034051）
广东省医学科研基金(A2008308) （A2008308）
广东药学院科研启动基金(2007jcx02) （2007jcx02）
