广东药学院学报2011，Vol.27Issue(1)：94-98,5.DOI:10.3969/j.issn.1006-8783.2011.01.024
染料木素的神经保护作用及其机制的研究进展
Research progress on neuroprotective effect and its mechanisms of genistein
摘要
Abstract
Genistein widely exists in legumes, and as a phytoestrogen, is applied in pharmaceutical industry-,nutritional products and so on. It is proved that genistein has neuroprotective effects through the mechanisms of anti-oxidation, resisting A beta(Al3) toxicity, adjusting neurotrophic factor expression, regulating intracellular Ca2+ concentration, reducing the neuro-toxicity of glutamine, inhibiting the nerve cell apoptosis, regulating signal transduction pathway and increasing the hippocampus neuropeptide Y expression, etc. Based on domestic and overseas scholars' researches in recent years on the treatment of Alzheimer's disease (AD) with genistein, developments of the neuroprotective effects of genistein are reviewed.关键词
染料木素/神经保护/阿尔茨海默病Key words
genistein/ neuroprotective effect/ Alzheimer' s disease分类
中医学引用本文复制引用
罗思婧,黄庆,任冬冬,廖维良,杨红..染料木素的神经保护作用及其机制的研究进展[J].广东药学院学报,2011,27(1):94-98,5.基金项目
广东省社会发展计划工业攻关项目(2005810401005) （2005810401005）
广东省科技计划农业攻关项目(201013020312016) （201013020312016）
