国际妇产科学杂志2011，Vol.38Issue(1)：53-55,71,4.
肝癌缺失基因家族与肿瘤关系的研究进展
Research Progress in the Relationships Between Deleted in Liver Cancer Genes Family and Tumors
摘要
Abstract
Deleted in liver cancer genes (DLCs) family is found in several human tissues, and expresses Rho GTPase activation proteins (RhoGAP). Recent studies have suggested that DLCs were underexpressed or absent in various types of human cancers. DLCs negatively regulated Rho proteins, focal adhension proteins and their downstream effectors to restraint cellular cytoskeletal formation and focal adhesion reorganization and played important roles in tomorigenesis, cell proliferation, invasion and migration, DLCs proteins play roles in estrogen, progestin and insulin related tumors, since they can regulate the activities of DLCs proteins by post-translational modification.关键词
肝肿瘤/基因缺失/细胞增殖/肿瘤侵润/肿瘤转移Key words
Liver neoplasms/ Gene deletion/ Cell proliferation/ Neoplasm invasiveness/ Neoplasm metastasis引用本文复制引用
张海玲..肝癌缺失基因家族与肿瘤关系的研究进展[J].国际妇产科学杂志,2011,38(1):53-55,71,4.基金项目
河南省2009年度医学科技攻关计划项目(20090113) （20090113）
