畜牧与兽医2011，Vol.43Issue(1)：20-23,4.
桦褐孔菌多糖对感染弓形虫小鼠治疗作用及其对血清中细胞因子含量的影响
Effect of Inonotus obliquus polysaccharide on survival and cytokines in sera of mice infected with Toxoplasma gondii
摘要
Abstract
The aim of this study was to investigate the effect of Inonotus obliquus polysaccharide against Toxoplasma gondii and to analyze the cytokine response in murine models of infection with T. gondii RH strain. The mice in the medium-dose group had the highest survival rate and the longest survival time. The analysis for cytokines showed that the levels of IFN-γ in the medium-dose and high-dose groups were significantly higher than those in other groups ( P＜0. 001). The IL-2 levels between the high-dose group and other groups were very significantly different (P＜0. 001 ) . It suggested that the medium-dose of Inonotus obliquus polysaccharide had high activity against T. gondii in vivo and might make IFN-γ and IL-2 increase to the appropriate level, thus decreasing the damage of T. gondii infection to mice.关键词
桦褐孔菌/多糖/治疗作用/弓形虫/细胞因子分类
农业科技引用本文复制引用
李佳佳,鞠玉琳,张厚双,于龙政,李杨..桦褐孔菌多糖对感染弓形虫小鼠治疗作用及其对血清中细胞因子含量的影响[J].畜牧与兽医,2011,43(1):20-23,4.基金项目
国家自然科学基金(30860211). （30860211）
