重庆医学2011，Vol.40Issue(3)：239-241,3.DOI:10.3969/j.issn.1671-8348.2011.03.012
不明原因肝功能异常患者自身抗体的检测及对自身免疫性肝病的临床意义
The detection of autoantibody and autoimmune liver disease in patients with abnormal liver function of unknown etiology
陈瀑 1严立 1叶荻庆 1祝继华 1张莉萍1
作者信息
- 1. 重庆医科大学附属第一医院检验科,400016
- 折叠
摘要
Abstract
Objective To study autoimmune liver disease clinics status quo in order to raise awareness of the disease and the di agnosis level. Methods 186 cases of patients with abnormal liver function of unknown etiology in our hospital from 2007 to 2010 were studied retrospectively according to the main features of laboratory analysis. Results Among the 186 cases, 31.7％ of them showed autoantibody positive with 42 cases ANA positive(22.6 ％ ), 14 cases AMA positive(7.4 ％ ), 5 cases SMA positive(2.7 ％ ), 0 case LKM positive. The positive rate of autoimmune hepatitis and primary biliary cirrhos were 9. 7％ and 7. 5％ respectively. ANA and AMA showed in autoimmune hepatitis and primary biliary cirrhosis with the highest positive rate respectively. The titer of autoantibody in 95 percent of patients with autoimmune liver disease was ≥1: 320. ALP and GGT in primary biliary cirrhosis patients were higher than those in autoimmune hepatitis(P＜0.05). Conclusion High autoantibody titers of autoimmune liver dis ease have diagnostic value,analysis of liver function immune globulin, serum protein electrophoresis, and other laboratory data also contribute to antoimmune liver disease diagnosis.关键词
肝炎,自身免疫性/肝硬化,胆汁性/自身抗体Key words
hepatitis/ autoimmune/ liver cirrhosis/ biliary/ autoantibodies引用本文复制引用
陈瀑,严立,叶荻庆,祝继华,张莉萍..不明原因肝功能异常患者自身抗体的检测及对自身免疫性肝病的临床意义[J].重庆医学,2011,40(3):239-241,3.
