重庆医学2011，Vol.40Issue(2)：113-114,2.DOI:10.3969/j.issn.1671-8348.2011.02.004
CD38在139例儿童急性淋巴细胞白血病中的表达及其临床意义
Clinical significance of CD38 expression in childhood acute lymphocytic leukemia
张耀东 1胡群 2刘双又 2张柳清 2刘爱国 2孙燕 2熊昊2
作者信息
- 1. 新乡医学院,河南,453003
- 2. 华中科技大学同济医学院附属同济医院儿科,武汉,430030
- 折叠
摘要
Abstract
Objective To explore the clinical significance of CD38 expression in childhood acute lymphocytic leukemia(ALL).Methods The expression of CD38 and immunophenotype in 139 cases with ALL were analyzed by flow cytometry. According to the expression of CD38,all the cases were divided into CD38 positive expression group (n= 31)and CD38 negative expression group(n = 108). The clinical feature of the two groups and complete remission rates of the first chemotherapy were compared. Results The positive expression of CD38 in 139 cases with ALL was 31 cases (22.30 ％). The results showed that CD38+ -ALL was significantly related with CD38--ALL cells in splenomegoly,lymphadenopathy and hepatomegaly. There was no relationship between CD38 expression and other indicators of ALL. The complete remission rates of the CD38 1 -Al group and CD38- -ALL group had no significant difference. Conclusion The expression of CD38 is helpful for the condition of ALL in children. But it cannot be as a inde pendent prognostic indicator in ALL.关键词
白血病,淋巴样/流式细胞术/儿童/CD38Key words
leukemia/ lymphocytic / flow cytometry / child / CD38引用本文复制引用
张耀东,胡群,刘双又,张柳清,刘爱国,孙燕,熊昊..CD38在139例儿童急性淋巴细胞白血病中的表达及其临床意义[J].重庆医学,2011,40(2):113-114,2.
