郑州大学学报（医学版）2011，Vol.46Issue(1)：31-34,4.
肝细胞癌组织中三磷酸腺苷结合盒转运体G2和CD133蛋白的表达
Expression of ABCG2 and CD133 protein in hepatocellular carcinoma tissue
摘要
Abstract
Aim:To investigate the protein expressions of ABCG2 and CD133 in hepatocellular carcinoma (HCC) tissue. Methods:The protein expressions of ABCG2 and CD133 in 48 cases of HCC and normal tissues were detected using immunohistochemistry methods. ResultS:The positive expression rate of ABCG2 protein in HCC tissue[47. 9% (23/48) ] was significantly higher than that of the tumor-adjacent tissue[22. 9% ( 11/48) ] (X2 = 10. 083, P <0. 001 ). The positive expression of ABCG2 protein was associated with differentiation degree (X2 =5. 298, P = 0. 021) , capsule violation(X2 = 15.068, P<0.001), and portal vein thrombosis (X2 =17. 146,P <0.001). The positive expression rate of CD133 in HCC tissue (27. 1% ) was significantly higher than that of the tumor-adjacent tissue(0% ) (X2 = 11.077,P <0.001). The positive expression of CD133 protein was associated with differentiation degree (X2 =6.553, P =0.010), capsule violation (X2 = 24. 382, P < 0. 001) , and portal vein thrombosis(X2 = 16.032, P < 0. 001) . Conclusion: The abnormal expression of ABCG2 and CD133 protein may be involved in the development,invasion and metastasis of HCC.关键词
肝细胞癌/三磷酸腺苷结合盒转运体G2/CD133Key words
hepatocellular carcinoma/ ATP-binding cassette transporter G2/CD133分类
医药卫生引用本文复制引用
黄涛,宫东伟,周进学,董子明..肝细胞癌组织中三磷酸腺苷结合盒转运体G2和CD133蛋白的表达[J].郑州大学学报（医学版）,2011,46(1):31-34,4.基金项目
河南省科技厅基础与前沿研究基金资助项目 082300450100 （）
