安徽农业科学2011，Vol.39Issue(2)：1076-1078,3.
替米考星β-环糊精聚合物微球的制备与表征
Preparation and Characterization of Tilmicosin β-Cyclodextrin Polymer Microspheres Inclusion Compound
摘要
Abstract
[ Objective ]To optimize the preparation technology of Tilmicosin β-cyclodextrin polymer micro-spheres inclusion compound. [ Method] Tilmicosin β-cyclodextrin polymer microspheres inclusion compound was prepared by coprecipitation method. The preparation process was optimized through the L9(34) orthogonal experimental design, the regression analysis was based on the evaluation indicators of drug produce and encapsulation efficiency. Tilmicosin β-cyclodextrin polymer microspheres inclusion compound was characterized by SEM,laser particle analyzer,FT-IR spectroscopy and thermo gravimetric analysis (TGA). [ Result]The best technological conditions were showed as following: the quantity of β-cyclodextrin polymer mierospheres,Tilmicosin were 3 g,0.25 g respectively,the reacting temperature was 50 ℃, the reacting time was 3 h, stirring speed was 600 r/min. Under optimum conditions, the produce and drug encapsulation efficiency were 83.32% and 67.61% respectively.Through optimizing the preparation process,the loaded microspheres were endowed with good shape,and the average diameter of microparticle was 161.35 μm. Tilmicosin was dispersed with amorphous in microspheres,and it was ensured with good thermal stability. [ Conclusion ]The preparation method was reasonable and feasible.关键词
β-环糊精聚合物微球/替米考星/回归分析法Key words
β-cyclodextrin polymer microspheres/Tilmicosin/Regression analysis分类
农业科技引用本文复制引用
李仲谨,韩春鹏,苗宗成,赵燕,杨威,赵艳..替米考星β-环糊精聚合物微球的制备与表征[J].安徽农业科学,2011,39(2):1076-1078,3.基金项目
国家自然科学基金项目(50573046) （50573046）
陕西省教育厅产业化培育项目(02JC05). （02JC05）
